RISK ASSESSMENT FOR JAPANESE ENCEPHALITIS VACCINATION

Risk assessment for Japanese encephalitis vaccination

Japanese encephalitis (JE) is the most commonly diagnosed viral encephalitis in Asia.JE is caused by a virus called JE virus (JEV), a member of the genus Flavivirus, family Flaviviridae, and is transmitted by Culex mosquitoes.Neutralising antibody to JEV protects against JE, and can be induced by vaccination.JE is a potential threat to travellers t

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A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation.

Endoplasmic reticulum-associated degradation (ERAD) is a protein quality control pathway of fundamental importance to cellular homeostasis.Although multiple ERAD pathways exist for targeting topologically distinct substrates, all pathways require substrate ubiquitination.Here, we characterize a key role for the UBE2G2 Binding Region (G2BR) of the E

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